abstract：:The quantitative determination of coumarins, flavonoids and chlorogenic acid in the leaves and underground parts of Scopolia carniolica Jacq., S. lurida Dun. and S. sinensis Hemsl. using the RP-HPLC method has been described. ...

journal_title：Acta poloniae pharmaceutica

authors： Nowak S,Dzido TH,Soczewiński E,Wolbiś M

更新日期：2002-07-01 00:00:00

abstract：:The aim of this study was to apply high performance liquid chromatography to the determination of content of desmopressin in pharmaceutical preparations and validation of the method. The satisfactory results have been obtained using a column Luna C 8.5 microm, 100 x 4.6 mm and a mobile phase containing 0.067 M phospha...

journal_title：Acta poloniae pharmaceutica

authors： Dudkiewicz-Wilczyńska J,Snycerski A,Tautt J

更新日期：2002-05-01 00:00:00

abstract：:A new oxime, 3-hydroxyimino-5-methyl-2-hexanone (HIMH) has been synthesized by the reaction of 1-pentyl nitrite with 5-methyl-2-hexanone under acidic conditions. The subsequent treatment of HIMH with NH2OH x HCl gives 5-methyl-2,3-hexanedione dioxime (H2MHDDO). The structures of these compounds have been confirmed by ...

journal_title：Acta poloniae pharmaceutica

authors： Patil VR,Donde KJ,Jadhav SB,Malve SP

更新日期：2002-05-01 00:00:00

abstract：:It was found that MCCh may be used for the enhancement of the solubility and dissolution rates of drugs. The solubility of IBA in water increased significantly (about 10-fold) when MCCh was added. Differential scanning calorimetry (DSC), powder X-ray diffractometry, and IR spectroscopy were used to confirm that salt l...

journal_title：Acta poloniae pharmaceutica

authors： Bodek KH

更新日期：2002-03-01 00:00:00

abstract：:The selected essential oil components (menthol, (+)bomeol, geraniol, linalool, carvone, camphor, (IR)-(-)fenchone) were separated by adsorption thin-layer chromatography using benzene as mobile phase. Investigated terpenes were characterized by selected topological indexes based on the adjacency and distance matrix. F...

journal_title：Acta poloniae pharmaceutica

authors： Pyka A,Bober K,Gurak D,Niestroj A

更新日期：2002-03-01 00:00:00

abstract：:Influence of different concentrations of ascorbic acid (vitamin C) and dl-alpha-tocopherol acetate (vitamin E) on in vitro cytotoxic adriamycin activity, in: embryonic human fibroblasts (CLV102), human melanoma cells (ME18) and adriamycin-resistant subline cells (ME18/R), was studied. IC50 value for each compound (com...

journal_title：Acta poloniae pharmaceutica

authors： Woźniak G,Anuszewska EL

更新日期：2002-01-01 00:00:00

abstract：:A thin layer chromatographic-densitometric method for the identification and determination of kawain in a mixture of kavalactones obtained from a methanol extract of kava-kava roots (Piper methysticum) was developed. The main compounds present in the extract were separated with good results using silica gel F 254 coat...

journal_title：Acta poloniae pharmaceutica

authors： Janeczko Z,Krzek J,Pilewski N,Walusiak D

更新日期：2001-11-01 00:00:00

abstract：:Spectrophotometric and chromatographic (HPLC) methods for determination of hydrochlorothiazide, triamterene and propranolol hydrochloride were elaborated. Both methods were appropriate for the determination of three compounds in pharmaceutical preparations containing their mixtures. Both the elaborated methods for the...

journal_title：Acta poloniae pharmaceutica

authors： Jończyk A,Nowakowska Z

更新日期：2001-09-01 00:00:00

abstract：:The economical method of daunorubicin purification was evaulated. ...

journal_title：Acta poloniae pharmaceutica

authors： Sławiński W,Oszczapowicz I,Cichocka K,Zimniak A

更新日期：2001-07-01 00:00:00

abstract：:Dipicrylamine reacts in neutral medium with some 2,10-disubstituted phenothiazines (promazine, chlorpromazine and promethazine hydrochlorides, trifluoperazine dihydrochloride, thioproperazine dimethanosulphonate) forming orange or brown ion-association compounds. The compounds are insoluble in water but quantitatively...

journal_title：Acta poloniae pharmaceutica

authors： Regulska E,Puzanowska-Tarasiewicz H

更新日期：2001-05-01 00:00:00

abstract：:6-Chloro-, 6-morpholino- and 6-N-methylpiperazino-1,2,4-triazolo[4,3-b]- or 1,2,3,4-tetrazolo[1,5-b]pyridazines [II-VII] were synthesized from 3-chloro-6-hydrazinopyridazine [I]. Positive effect of a series of tetra- and triazolopyridazines for lowering blood-pressure without affecting the heart rate was found in test...

journal_title：Acta poloniae pharmaceutica

authors： Katrusiak A,Melzer E,Bałoniak S,Bobkiewicz T,Polcyn P

更新日期：2001-05-01 00:00:00

abstract：:The following compounds from the flowers of Kitaibelia vitifolia were isolated and identified: kaempferol 3-O-(6"-p-coumaroyl)-beta-glucoside (trans-tiliroside); quercetin and kaempferol - 3-O-beta-xylopyranosyl (1-->2)-beta-glucopyranoside (3-O-sambubioside): quercetin and kaempferol - 3-O-sambubioside-7-O-glucoside;...

journal_title：Acta poloniae pharmaceutica

authors： Matławska I

更新日期：2001-03-01 00:00:00

abstract：:Microcapsules of isoniazid were prepared by phase separation coacervation process induced by non-solvent addition and using ethylcellulose (EC) as coating polymer. When polyisobutylene (PIB)--a protective colloid was present at sufficient concentration, film coated drug particles were formed. At 0-6% PIB concentration...

journal_title：Acta poloniae pharmaceutica

authors： Barik BB,Ray S,Goswami N,Gupta BK,Ghosh LK

更新日期：2001-01-01 00:00:00

abstract：:5-Aminolevulinic acid is at present most popular precursor of photosensitizer for photodynamic therapy and diagnostics. The effect of accumulation of PpIX induced by exogenous ALA is based on the avoidance of feedback control in the pathway of heme biosynthesis. For use ALA in medicine, development of analytical metho...

journal_title：Acta poloniae pharmaceutica

authors： Chmielowiec U,Kwaśny M

更新日期：2000-11-01 00:00:00

abstract：:In present study the structure-selectivity relationship of buspirone and six of its analogues towards 5-HT1A and 5-HT2A serotonin receptors was investigated on molecular level. Molecular mechanics energy minimisation and advanced molecular dynamics (MD) simulations allowed us to perform a dynamic structural analysis o...

journal_title：Acta poloniae pharmaceutica

authors： Bronowska A,Sylte I,Edvardsen Ø,Østensen R,Leś A,Chilmonczyk Z

更新日期：2000-11-01 00:00:00

abstract：:The seven-stage synthesis of a pyrrole analogue of chloramphenicol (VII) was described. The compound exhibits a significant antibacterial activity. ...

journal_title：Acta poloniae pharmaceutica

authors： Krajewska D,Dabrowska M,Jakoniuk P,Rózański A

更新日期：2000-11-01 00:00:00

abstract：:The effect of gamma irradiation, in doses from 10 to 50 kGy on physical and chemical properties of metronidazole, ornidazole and tynidazole in solid state has been studied. Results of the measurements by the UV, IR, TLC, EPR, DSC methods revealed the presence of free radicals, products of decomposition, an increase in...

journal_title：Acta poloniae pharmaceutica

authors： Marciniec B,Ogrodowczyk M,Ambroz H,Przybytniak G

更新日期：2000-11-01 00:00:00

abstract：:Considering importance of the lipophilicity of norethindrone (log P=2.97), a significant contributor to its mechanism of action, interaction of the drug with total lipids of goat whole blood have been investigated using phospholipid binding, fatty acid composition and peroxidation phenomena as the parameters under inv...

journal_title：Acta poloniae pharmaceutica

authors： Saha A,Roy K,De K,Sengupta C

更新日期：2000-11-01 00:00:00

abstract：:The chemical behaviour of L-ascorbic acid (H2Asc) with cadmium (II) and zinc (II) in alkaline medium was studied. The total stability constants of the examined complexes and their composition were determined by spectrophotometry (Jacymirsky and computer) method. An attempt has been made to explain the nature of comple...

journal_title：Acta poloniae pharmaceutica

authors： Kleszczewska E,Misiuk W

更新日期：2000-09-01 00:00:00

abstract：:Influences of cellulose derivatives (with and without additives of humectants) on two parameters, namely the liberation of the potential local anaesthetic XX Z and the structural viscosity of preparations were compared. The aim was to select a suitable base for topic application of the substance XX Z, chemically pyrro...

journal_title：Acta poloniae pharmaceutica

authors： Vitková Z,Gardavská K,Cizmárik J,Rak J

更新日期：2000-09-01 00:00:00

abstract：:The contents of active substances were determined in a preparation TP-4 (tablets) containing paracetamol, ascorbic acid, caffeine and phenylephrine hydrochloride. For determination of caffeine and phenylephrine hydrochloride, UV/VIS spectrophotometric method was used. The VIS spectrophotometric method based on the rea...

journal_title：Acta poloniae pharmaceutica

authors： Muszalska I,Zajac M,Wróbel G,Nogowska M

更新日期：2000-07-01 00:00:00

abstract：:The alpha-oxo ketene dithioacetalic derivatives (2a-e) were obtained by the reaction of 2-acetylpyrazine (1) with CS2 and appropriate mono- or dihalogeno-compound. An action of the primary amines and diamines upon 3,3-di(methylsulphanyl)-1-(2-pyrazinyl)-2-propen-1-one (2a) yielded 3-(alkylamino)-3-(methylsulphanyl)-1-...

journal_title：Acta poloniae pharmaceutica

authors： Milczarska B,Foks H,Mikołajczyk K,Janowiec M,Zwolska Z,Andrzejczyk Z

更新日期：2000-07-01 00:00:00

abstract：:In the reaction of phenylacetic acid hydrazide or malonic acid hydrazide with isocyanates, new derivatives of semicarbazide were obtained [I-VIII]. Cyclization of these derivatives with a aqueous 2% sodium hydroxide led to the formation of new derivatives of delta 2-1,2,4-triazolin-5-one [IX-XVI]. Some of them were in...

journal_title：Acta poloniae pharmaceutica

authors： Dobosz M,Pachuta-Stec A,Tokarzewska-Wielosz E,Jagiełło-Wójtowicz E

更新日期：2000-05-01 00:00:00

abstract：:Fourteen new potentially biologically active 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analysis, 1H NMR, IR and UV spectra. Three of these compounds were screened for their antitumor activities. ...

journal_title：Acta poloniae pharmaceutica

authors： Kahveci B,Ikizler AA

更新日期：2000-03-01 00:00:00

abstract：:Iridoids and phenylethanoids were separated from Verbena bipinnatifida Nutt. (Verbenaceae). The compounds identified are pulchelloside I and II--iridoids and martynoside, verbascoside-phenylethanoids. The structures of all the compounds isolated were elucidated by classical and spectroscopic methods. ...

journal_title：Acta poloniae pharmaceutica

authors： el-Hela AA,Sowiński P,Krauze-Baranowska M

更新日期：2000-01-01 00:00:00

abstract：:The interferon inducing abilities of eleven ethanolic extracts obtained from nine taxons of Polygonum L. genus, were tested in the cell culture of monkey kidney. The extracts from the herb of Polygonum amphibium L. and the rhizome and fruit of Polygonum bistorta L. induced a substance showing an interferon-like activi...

journal_title：Acta poloniae pharmaceutica

authors： Smolarz HD,Skwarek T

更新日期：1999-11-01 00:00:00

abstract：:New bis[6-phenyl-4-methyl-3-substituted-pyrazo[4,5-d] pyrazol-1-yl]thioketones have been obtained in good yield by the reaction of thiocarbohydrazine with 1-phenyl-3-methyl-4-acetyl/benzoyl-pyrazol-5-one, followed by cyclization of the intermediate. The new compounds exhibit excellent antimicrobial activity. ...

journal_title：Acta poloniae pharmaceutica

authors： Chande MS,Thakkar NV,Patil DV

更新日期：1999-05-01 00:00:00

abstract：:Various species of Taxus contain taxanes that promote polymerization and stabilization of microtubules. They have been reported as antineoplastic compounds with highly effective chemiotherapeutic application. A decrease in incorporation of the radiolabelled precursors into DNA, RNA and proteins in vivo has been report...

journal_title：Acta poloniae pharmaceutica

authors： Sredzińska K,Gajko A,Gałasiński W,Gindzieński A

更新日期：1999-01-01 00:00:00

abstract：:The effects of scavengers on the cytotoxicity of dihydralazine were evaluated. Pretreatment of two kinds of mammalian cells cultured in vitro with catalase or sodium dismutase abolished partially or almost totally the effects of the drug. Hydroxyl radicals scavengers dimethylsulphoxide and D-mannitol minimized the cyt...

journal_title：Acta poloniae pharmaceutica

authors： Marczewska J,Koziorowska JH

更新日期：1998-07-01 00:00:00

abstract：:Properties of a new crystalline beta-from of 1-acetoxyethyl ester of cefuroxime have been investigated and compared with known alpha-from and the amorphous form of this ester. Differences between these forms are discussed. ...

journal_title：Acta poloniae pharmaceutica

authors： Oszczapowicz I,Tejchman B,Zimniak A,Oszczapowicz J

更新日期：1998-05-01 00:00:00

abstract：:The paper reports results of the studies of sulfonamide tablets obtained by the incorporation in hydrophilic carrier (Cellulose ether). The rate of sulfonamide release was determined by the paddle method. The occurrence of physical and chemical interactions of sulfonamides and cellulose ethers in the solid phase was c...

journal_title：Acta poloniae pharmaceutica

authors： Hładoń T,Cwiertnia B

更新日期：1997-11-01 00:00:00

abstract：:A novel synthesis of 5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones is described. The method is based on Ullmann condensation of 2-chloronicotinic acid and its 5-bromo analoguewith 2-aminopyridine 1-oxides, followed by intramolecular cyclization of the resulting 3-carboxy-2,2'-bipyridylamine 1'-oxides with phosphorous. ...

journal_title：Acta poloniae pharmaceutica

authors： Rykowski A,Pucko W

更新日期：1997-07-01 00:00:00

abstract：:HPLC was applied to the quantitative assay of seven free phenolic acids from the leaves, roots and seed testas of Ginkgo biloba L. (Ginkgoaceae). The concentration of the free phenolic acids amounted to: 19.693 micrograms/g of fresh leaves, 345.321 micrograms/g of roots and 2.708 micrograms/g of testas: protocatechuic...

journal_title：Acta poloniae pharmaceutica

authors： Ellnain-Wojtaszek M

更新日期：1997-05-01 00:00:00

abstract：:A series of appropriate aminoalkanolic derivatives of xanthone III-VIII was synthesized and evaluated as potential antiarrhythmic agents. They were also tested for the effect on the cardiovascular system. The structure of the synthesized compounds was verified by IR 1H NMR, 13C NMR and mass spectral data. ...

journal_title：Acta poloniae pharmaceutica

authors： Marona H,Szneler E,Filipek B,Sapa J

更新日期：1997-01-01 00:00:00

abstract：:A series of 2-[5-chloro-4-methyl-2-(perhydropyrimidin-2-yl iminosulphonyl)phenylthio]alkanoic acids [IV-XI], their methyl esters [XII-XIX], N-(2-dimethylaminoethyl) amides, [XX-XXV] and the corresponding hydrochlorides [XXa-XXIVa] were obtained. The hydrochlorides [XXa, XXIIa, XXIVa] exhibited a comparable or stronger...

journal_title：Acta poloniae pharmaceutica

authors： Pomarnacka E,Oledzka K

更新日期：1996-11-01 00:00:00

abstract：:The influence of catalase activity in adriamycin and bleomycin mutagenesis was investigated in Salmonella typhimurium TA98 and TA102, respectively. The activity of catalase in bacterial cells was inhibited by sodium azide. Mutagenicity of both drugs was not changed in bacterial cells with depressed catalase activity. ...

journal_title：Acta poloniae pharmaceutica

authors： Ejchart A,Chłopkiewicz B

更新日期：1996-09-01 00:00:00

abstract：:Continuous fluorimetric assay for aldehyde dehydrogenase activity in rat tissue, based on oxidation of the fluorogenic 6-methoxy-2-naphthaldehyde, is described. The new assay is ca. 2 orders of magnitude more sensitive than the standard procedures and it is not subjected to interferences by other dehydrogenases, altho...

journal_title：Acta poloniae pharmaceutica

authors： Wierzchowski J,Wroczyński P,Interewicz E

更新日期：1996-05-01 00:00:00

abstract：:The role of reactive oxygen species in adriamycin and bleomycin-induced mutagenicity was investigated in Salmonella typhimurium TA98 and TA102 respectively. Activity of superoxide dismutase (SOD) was inhibited by preincubation of bacteria with diethyldithiocarbamate (DEDTC). Results of Ames test may suggest the involv...

journal_title：Acta poloniae pharmaceutica

authors： Ejchart A,Marczewska J,Chłopkiewicz B

更新日期：1996-01-01 00:00:00

abstract：:Although a number of properties of bisphosphonates have been recognized which influence the metabolic process in bones, particularly those concerning the remodelling processes, the influence of this new group of drugs on the mechanical properties of bones remains an open issue. In order to clarify this problem, the pr...

journal_title：Acta poloniae pharmaceutica

authors： Kaczmarczyk-Sedlak I

更新日期：1995-11-01 00:00:00

abstract：:The influence of selected general anesthetics: thiopental, propofol, ketamine and pentobarbital on the lidocaine pharmacokinetic parameters was studied in rabbits. Thiopental, ketamine and propofol caused a decrease of lidocaine blood level, but pentobarbital caused its increase. Pentobarbital, thiopental and ketamine...

journal_title：Acta poloniae pharmaceutica

authors： Orszulak-Michalak D

更新日期：1995-07-01 00:00:00